Rejuvenating SIRT1 Activators
نویسندگان
چکیده
منابع مشابه
Dietary activators of Sirt1.
Calorie restriction (CR) is a non-genetic manipulation that reliably results in extended lifespan of several species ranging from yeast to dogs. The lifespan extension effect of CR has been strongly associated with an increased level and activation of the silent information regulator 2 (Sir2) histone deacetylase and its mammalian ortholog Sirt1. This association led to the search for potential ...
متن کاملSIRT1 Activators: The Evidence STACks up
The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters.
متن کاملPharmacophore Mapping and Virtual Screening for SIRT1 Activators
Division of Applied Life Science (BK21 Program), Environmental Biotechnology National Core Research Center(EB-NCRC), Plant Molecular Biology and Biotechnology Research Center (PMBBRC), Gyeongsang National University, Jinju 660-701, Korea. *E-mail: [email protected] †Bio Computing Major, Korean German Institute of Technology, Seoul 157-033, Korea ‡Division of Quality of Life, Center of Bioanalysis...
متن کاملRejuvenating regeneration
the transcriptional coactivator CREB-binding protein, also known as CREBBP or CBP, maximizes embryonic neural precursor cell development. 5 These researchers also demonstrated that the effects of CBP on neurogenesis require CBP activation by atypical protein kinase C (aPKC). Because Wondisford and colleagues had demonstrated that metformin's ability to suppress hepatic gluconeogenesis requires ...
متن کاملRejuvenating tithonus.
Tennyson tells us of Tithonus, who was endowed with immortality and was never permitted to perish, despite his wishes to that end. A biological parallel might be pluripotent stem cells, which can be indefinitely propagated in vitro in an uncommitted, self-renewing state, and can form all lineages in the mammalian body [1]. However, pluripotency is an inherently transient condition in vivo. Thus...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2013
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2013.04.016